ES3 Stack
60 Caps (1-2 months)
$39.95
(Retail $109.95)
275% Piranha Savings
120 Caps (2-4 months)
$69.95
(Retail $129.95)
186% Piranha Savings
ES3 STACK
Triple Action Anti-Aromatase
The ES3 Stack is a cutting edge anti-aromatase product that is a must when following up a prohormone or steroid cycle or for anyone who is looking for a fast effective way to boost free testosterone. ES3 Stack incorporates the three strongest aromatase inhibitors known with DHB for optimal absorption and long term bioavailability. 4-etioallocholen-3,6,17-trione is the ever popular 6-OXO molecule. 6, 17-keto-eticholeve-3-ol tetrahydropyranol and 3-17-keto-etichol-triene are the two anti-aromatase compounds used in the popular and effective Novadex XT from Gaspari Nutrition only Scifit has doubled the dose per cap making the ES3 Stack an incredibly potent free-testosterone booster and estrogen assassin!
Here is how the compounds work :
4-etioallacholen-3,6,17 trione 300 MG (better known as 6-OXO)
This compound has been renamed to conform (really to get around) to the new andro ban law. It use to be 3,6,17Androstenetrione.
Below is a description of the 6-OXO compound from the inventing company Ergopharm.. We felt it gave the best description of the compound to you the consumer.
The First Effective All Natural Aromatase Inhibitor!
For athletes familiar with prohormones and steroids, the female hormone estrogen is undoubtedly a familiar enemy. While most of us understand that estrogen is not necessarily always a harmful and worthless substance to men (in the right amounts it is necessary and beneficial), we still are aware that it must be kept under control or some pretty undesirable conditions may arise in the body.
The Evils of Estrogen
In males, higher than normal estrogen levels (or estrogen levels that are out of balance with androgen levels) can lead to several physiological disturbances. The most well known estrogen induced malady is, of course, gynecomastia (aka gyno or bitch tits). Gyno, simply put, is the growth of breast tissue in men. Usually gyno is a benign growth that is little more than a cosmetic nuisance, however it occasionally (rarely) can become malignant and lead to male breast cancer. Either way, it is something than definitely is anathema to any guy that takes pride in his physical appearance and musculature. Rock hard pecs topped off with puffy cone shaped girlie lumps are simply not for showing off - at least not in my neighborhood.
High estrogen can also promote excessive water and sodium retention, resulting in a bloated, puffy, and smooth appearance. Steroids that aromatize heavily (such as testosterone and Anadrol) are renowned for putting on lots of bodyweight. However, that body weight usually is in large part estrogen induced water retention, and certainly not all muscle.
If all this is not enough then there is the potent inhibitory effect of estrogen on the hypothalamus, resulting in a shutdown of testicular testosterone production. Science has demonstrated that perhaps the most important regulator of testosterone production in males is estrogen - produced by the conversion of testosterone (and other androgens) to estrogen in the body and the brain. Estrogen sends a signal to the hypothalamus to shut down production of a substance known as GnRH. GnRH is a hormone that stimulates the pituitary to produce luteinizing hormone (LH) which is the signal that tells the testicles to produce testosterone. Therefore, men with elevated estrogen levels will have suppressed testosterone levels and perhaps even atrophied testes. Not a pretty picture, eh?
Controlling estrogen in males
Bodybuilders who use steroids caught on years ago to drugs that control estrogen in the body. The first drugs to be utilized were estrogen receptor antagonists such as tamoxifen and clomiphene. These drugs worked by binding to the estrogen receptor like estrogens do, but unlike estrogens they are unable to translocate to the nucleus and activate estrogen responsive genes. While these drugs are somewhat effective in countering gynecomastia and testicular shut down, they still retain some estrogenic activity in certain tissues such as the liver. The result of this residual estrogenic activity can be a reduction in IGF-1 production and an increase in sex hormone binding globulin (SHBG) production. These are both undesirable side effects.
Later on, bodybuilders discovered aromatase inhibitors. These drugs work by blocking the production of estrogens in the body through binding to the enzyme aromatase. Aromatase catalyzes the transformation of aromatizable androgens (i.e. androstenedione, testosterone) into estrogens such as estrone and estradiol. By actually blocking the production of estrogens altogether, aromatase inhibitors do not share the undesirable estrogen agonist activity of estrogen receptor blockers. Instead they function as true anti-estrogens, and because of this have arisen as the most preferred compounds for combating estrogen.
Before I go into detail about 6-OXO , I would like to give a very brief review and commentary on the current variety of estrogen blocking supplements.
The first estrogen blocking supplement to be introduced, and perhaps the most popular one to date is the isoflavone chrysin. Yes, chrysin has some good in-vitro ("test tube") research on it that demonstrates it blocks aromatase. However, for years many experts including myself have contended that it suffers from very poor bioavailability, and therefore is ineffective in-vivo. Recently, an article has been published in a very reputable journal that substantiates this suspicion.1 So chrysin, as promising as it once seemed, unfortunately appears to be a total bust.
After chrysin there was Indole-3-carbinol and Di-indoylmethane. These related compounds work by shifting the metabolism of estrogens away from strong estrogen compounds (16-hydroxylated) and towards weaker estrogens (2-hydroxylated). This can have benefits for women prone to breast cancer as 16-hydroxylated estrogens are quite notorious for promoting estrogen dependent breast cancer. However, there has never been any benefit demonstrated in men for reducing estrogen related effects or for increasing androgen levels. In fact, these compounds may actually REDUCE androgen levels.2 So for males looking to reduce estrogen and raise testosterone, I-3-C and DIM are poor choices.
In addition to these aforementioned compounds ere have been a slew of other compounds sold for estrogen control purposes. These include bioflavonoids such as quercitin, herbs such as Vitex Agnus Castus, and phytochemicals such as resveratrol (3,5,4'-trihydroxystilbene). None of these has ever been substantiated by any research to reduce estrogen levels or to increase testosterone levels.
After years of research into natural estrogen blockers I finally discovered a compound that really truly works, in males, to both reduce estrogen and increase testosterone. Its called 6-OXOT, which is short for 3,6,17-androstenetrione.
6-OXOT is what is known as a suicide inhibitor of aromatase. This means that 6-OXOT binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels.3 4 5 6 7 A corresponding increase in testosterone production is usually experienced as well.
It is important to note here that this deactivation of aromatase enzymes by 6-OXOT does not mean that your body becomes permanently deficient in the ability to synthesize estrogen. Your body will react to the deficiency of enzyme by producing more enzyme to replace that which has been deactivated. Therefore, when you stop taking 6-OXOT your aromatase enzyme level will quickly catch up to normal and full estrogen production will resume.
6-OXO is all natural as it is known to be an androgen metabolite formed in the adrenal and placenta.
The second ingredient in the ES3 Stack, 6, 17-keto-etiocholeve-3-ol tetrahydropyranol, is a patent-pending non-androgenic anti-aromatase that utilizes the advanced ether delivery technology. With its' ether attachment, this amazing compound has a prolonged half life in the human body which means you only take it once per day as opposed to many times per day like other anti-estrogens. The third amazing ingredient in the ES3 Stack, 3, 17-keto-etiochol-triene, is the single most potent non-androgenic aromatase inhibitor ever sold in the supplement market place! It is almost 3X more potent based on binding times and binding ability (how fast and tight it "sticks" to the target molecule) than 3,6,17-androstenetrione alone. The combination of a long acting non-androgenic anti-aromatase with the most potent non-androgenic anti-aromatase provides the smarter athlete with a double edge attack against the effects of estrogen and the prevention of estrogen formation. Because these two compounds actually minimize the production of any and all estrogen in the body through its' dual aromatase inhibition systems, this causes a positive effect on the HPTA which means it will actually cause your body to greatly increase testosterone production on it's own, the safest way to naturally cause a positive anabolic effect in order to gain muscle mass, strength, and endurance while helping to lose fat. Additionally, if you happen to be using or have recently used a prohormone or even a "real steroid," the HPTA upregulating effects will help your body to restore and normalize natural testosterone output and levels in the body and is the perfect LEGAL choice for post-cycle therapy (PCT).
NEW RESEARCH STUDIES UNDERWAY.
Recent clinical trials shows that the combination of 6, 17-keto-etiocholeve-3-ol tetrahydropyranol and 3, 17-keto-etiochol-triene increases bioavailable testosterone significantly higher (over 400%) and faster (within 2 weeks) than any other testosterone booster in the supplement industry - and with only a fraction of the dosage used by the leading brand! If this were not enough, the study also revealed that they were so effective at combating estrogen that estradiol was slashed an average of more than 50% in all subjects tested in just the 1st week! With this unprecedented 1-2 punch, this product is easily the most effective natural vehicle to trigger a potent anabolic response in order to help gain lean mass, strength and endurance while also helping to reduce body fat.
DHB 6',7',-dihydroxybergamottin
Super nutrient and anabolic enhancer. DHB enhances the bioavailability of almost all anabolic agents which is a welcome result when trying to get the most out of your supplement regimen. In the ES3 Stack, DHB not only protects the 3 active compounds from rapid destruction but also protects the new free testosterone from an early demise.
How is this groundbreaking anabolic agent accomplishing this? Break out your PDR, Chemistry and Anatomy books for this one. The active ingredient DHB is derived from the furanocoumarin family. There are literally hundreds of studies on this natural extract phenomenon in conjunction with pharmaceuticals showing dramatic, really dramatic increases in plasma (blood) drug concentrations when people ingest DHB with or around the same timeframe.
These results are especially impressive in drugs with notoriously low oral bioavailability, i.e. Drugs with a high first pass metabolism (Over 60% of drugs are destroyed by the first pass metabolism). The results of DHB use with pharmaceuticals have been so significant that Pharmacists and Doctors now warn against ingesting foods containing DHB with certain medications! The DHB could increase the blood plasma levels of drugs with normally low toxicity to dangerous levels!
There is one phrase above that may have caught your attention, "First Pass Metabolism". How many times have you heard that oral steroids and their close cousins' prohormones are destroyed or "Metabolized" in the first pass through the small intestine and liver? Large percentages of these anabolic hormone compounds are all metabolized (destroyed) by the isoenzymes CYP and P450 before they are able to enter the bloodstream. DHB actually prevents these enzymes from metabolizing or breaking down anabolic hormones!!
How Does it Work?
During the trip through the GI tract to the bloodstream, testosterone supplements travel through a destructive mine field laden with enzymes deadly to these hormone agents. This area begins in the small intestine and continues once the hormone enters the liver. These crucial sections of the digestive system contain enzymes, which are highly effective at attaching to anabolic molecules of testosterone making them inert and useless. These are the enzymes that pharmaceutical companies as well as supplement companies have spent millions of dollars trying to protect drugs and supplements from.
It has been said that the simplest answer is usually the correct one. DHB is a simple answer for this very complex and expensive problem. After years of attempts by companies to alter the prohormones and steroids to protect from the enzymes with some degree of success, we decided to attack the enzymes themselves.
DHB is designed to compete with the substrate hormone to attach itself to the enzyme. DHB has a stronger affinity to the enzyme than the hormone product resulting in these destructive enzymes attaching themselves harmlessly to DHB. The body then washes the enzyme harmlessly from the out of the body! Again, the enzymes CYP and P450 are the enzymes responsible for metabolizing and destroying steroids and prohormones. They can be removed from your body, paving the way for anabolic hormones to flood your bloodstream to yield massive muscle growth like never before!
Each 1 Capsule serving Contains:
4-etioallocholen-3,6,17-trione (6-OXO) 50 mg.
6, 17-keto-eticholeve-3-ol tetrahydropyranol 50 mg.
3-17-keto-etichol-triene 50 mg.
6',7',-dihydroxybergamottin (DHB) 50 mg.
For Maximum Testosterone Boost take ES3 Stack with SciFit's T-500!
Suggested Use: as an adult dietary supplement, take one capsule once daily. A second capsule may be taken prior to training.
Warning: Do not take DHB with any prescription medication. Do not exceed the recommended dose. Keep out of reach of children, consult your physician before use.